Allergic rhinitis, cough & cold

45 important questions on Allergic rhinitis, cough & cold

Nasal irrigations and wetting agents provide relief of what symptoms?

Nasal stuffiness, runny nose and sneezing

A nasal irrigation with premixed saline must be combined with what type of water? What type of water cannot be used and why?

Distilled, sterile or previously boiled & cooled water.
Do not use tap water ("drinking or potable")  because can cause infections.

1st line for chronic, moderate-severe symptoms

Intranasal steroids
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1st line for mild-moderate symptoms and have little effect on nasal congestion

PO antihistamines

1st line if congestion is present

Decongestants

How do the intranasal steroids work?

Decrease inflammation.
Great for reducing nasal symptoms

Main side effect of intranasal steroids

Epistaxis (nose bleeds)

Which intranasal steroids are preferred in pregnancy?

Budesonide (Rhinocort Allergy)
Beclomethasone

Which PO antihistamines are preferred and why?

2nd gen antihistamines because cause less sedation and cognitive impairment

Which 2nd gen antihistamines are preferred in pregnancy?

Loratadine (Claritin; + pseudoephedrine= Claritin-D)
Cetirizine (Zyrtec; + pseudoephedrine= Zyrtec-D)

Which 2nd gen antihistamines are MORE sedating?

Cetirizine (Zyrtec; + pseudoephedrine= Zyrtec-D)
Levocetirizine (Xyzal)

Which 2nd gen antihistamines are less sedating?

Fexofenadine (Allegra; + pseudoephedrine= Allegra-D)
Loratadine (Claritin; Claritin-D)

Which 2nd gen antihistamine should NOT be taken with fruit juice?

Fexofenadine (Allegra)

What are the main side effects of 1st gen antihistamines?

Somnolence, cognitive impairment, strong anticholinergic effects (dry mouth, blurred vision, urinary retention, constipation) and seizures/arrhythmias at higher doses

1st gen antihistamines should be AVOIDED in what populations?

<2 years old
Elderly
Prostate enlargement
Glaucoma

Which 1st gen antihistamine has a brand name approved for helping with sleep?

Doxylamine (Unisom SleepTabs)

Can diphenhydramine be used OTC in children <6 yrs old?

Not unless directed by doctor

What can also help with symptoms of allergic conjunctivitis (itchy, red eyes)

Antihistamines

What does it mean that decongestants are "sympathomimetics"?

They are alpha-adrenergic agonists that cause vasoconstriction to result in reduced sinus and nasal congestion

Systemic (PO) decongestants should be AVOIDED in what populations?

Children <2 (FDA) {children <4 according to package label}
cautiously use in CVD

Main side effects of the systemic (PO) decongestants

CV stimulation (tachycardia, palpitations, increased BP), CNS stimulation (anxiety, insomnia), decreased appetite

ALL decongestants are contraindicated if used within 14 days of?

MAO inhibitors

Are PO decongestants safe in the 1st trimester of pregnancy?

NO. AVOID.

Which systemic (PO) decongestant has poor oral absorption, which is why it also comes as a shorter acting nasal spray?

Phenylephrine (Sudafed PE)

Which systemic (PO) decongestant has restricted distribution because it is a precursor to methamphetamine?

Pseudoephedrine (Sudafed, Nexafed, Nephrex-D)

Since pseudoephedrine, phenylpropanolamine & ephedrine can all be converted to methamphetamine, they must be kept behind the counter, with a max of _______ allowed for purchase per day, and ______ total in a 30 day period.

3.6 grams per day
9 grams per 30 days 

Why can Oxymetazoline only be used for 3 days?

Can cause rhinitis medicamentosa (rebound congestion)

Which drug is started at onset of allergy symptoms and used regularly in order to be effective for prophylaxis & treatment of allergic rhinitis?

OTC mast call stabilizer: Intranasal cromolyn (NasalCrom)

Even though intranasal Cromolyn is not as effective as other agents, what is it safe to use in?

Children 2+
Pregnancy

Which drug is for treatment of allergic rhinitis and asthma, and commonly used in children?

Montelukast (Singulair)
[Leukotriene modifying agent]

What is a preventative treatment for allergies, either as SC or SL, that work by slowly increasing exposure to allergen?

Immunotherapy

How should the 1st dose of SL immunotherapy be given?

In a medical office and monitor at least 30 minutes for allergic reaction

Do ALL doses of SL immunotherapy have to be given in a medical office?

NO. If 1st dose is well tolerated, the next doses can be taken at home but the patient should have an epinephrine auto-injector

What are the 3 natural products for colds?

Zinc
Vitamin C (ascorbic acid)
Echinacea 

1st line if a productive cough is present in a cold

Expectorants to thin the mucus and move the secretions up/out of the respiratory tract

What is used for dry, non-productive cough or to suppress a productive cough as night?

Cough suppressants

How do opioids and dextromethorphan work to suppress cough?

Suppress the cough reflex

How does dextromethorphan work if used at low, usual antitussive doses?

Serotonin reuptake inhibitor

Why does dextromethorphan have abuse potential if used at high doses?

Acts as NMDA-receptor blocker, which causes similar effects as illicit drugs (euphoria, hallucinations)

Dextromethorphan is contraindicated if used within 14 days of what?

MAO inhibitor

Codeine is contraindicated in what populations?

Children less than 12 yrs of any reason
Children less than 18 yrs after tonsillectomy &/or adenoidectomy 

How does benzonatate work as a cough suppressant?

Topically works on the respiratory stretch receptors

For children <4 yrs with cough and cold

Avoid OTC cough & cold products (package label)

For children <2 yrs with cough and cold

Avoid OTC cough & cold products (FDA)
Avoid promethazine (FDA)
Avoid topical menthol & camphor (package label)

Why can any form of promethazine NOT be used in children <2 yrs?

Risk of fatal respiratory depression

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