Asthma - Drugs - Monoclonal antibodies for severe

7 important questions on Asthma - Drugs - Monoclonal antibodies for severe

When can monoclonal antibodies be used?

Severe asthma that is uncontrolled despite maximized treatment with inhaled meds

How are the biologic monoclonal antibodies given?

Injected

IgG monoclonal antibody for severe allergic asthma

Omalizumab (Xolair) SC
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Omalizumab (Xolair) MOA

Inhibits IgE binding on the IgE receptor on mast cells and basophils

How is omalizumab (Xolair) given?

SC every 2-4 weeks
Started in healthcare setting (BBW: anaphylaxis)

Interleukin receptor antagonists for severe eosinophilic asthma

Dupilumab (Dupixent) SC q other week
Benralizumab (Fasenra) SC q4w x4 doses, then q8w
Mepolizumab (Nucala) SC q4w
Reslizumab (Cinqair) IV q4w

Human thymic stromal lymphopoietin blocker for severe asthma of any type

Tezepelumab (Tezspire)

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