GERD/PUD - PUD

16 important questions on GERD/PUD - PUD

Mucosal erosion within the GI tract

Peptic ulcer disease (PUD)

Food effect on duodenal ulcers (from H. Pylori)

Pain is worse 2-3 hours after eating (when stomach is empty)

Food effect on gastric ulcers (from NSAIDs)

Pain worsens with eating
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H.pylori diagnostic test

Urea breath test (UBT) to detect CO2 produced by the H.pylori
Fecal antigen test to detect H.pylori in stool

When should PPIs, bismuth and abx be discontinued to avoid a false negative H.pylori test?

2 weeks before test

1st line for H. Pylori

Bismuth quadruple therapy for 10-14 days:
BSS QID + metronidazole QID + tetracycline QID + PPI BID

When should bismuth quadruple therapy be used, aside from 1st line?

High (>15%) clarithromycin local resistance rates
Previous macrolide exposure 
PCN allergy
Failed triple therapy

H. Pylori treatment if low (<15%) local clarithromycin resistance rates, no previous macrolide exposure, but is preferred if previous macrolide exposure

Concomitant therapy for 10-14 days:
Amox BID + clarithromycin BID + metronidazole BID + PPI BID 

H. Pylori treatment if low (<15%) local clarithromycin resistance rates and no previous macrolide exposure

Clarithromycin triple therapy for 14 days:
Amox BID + clarithromycin BID + PPI BID 
OR
amox + clarithromycin + lansoprazole (Prevpac)  

Combo to specifically reduce risk of NSAID induced ulcers

Naproxen/esomeprazole (Vimovo)

Secondary prevention of CV and cerebrovascular events in pt's at risk for aspirin induced ulcers

Aspirin/omeprazole (Yosprala)

Preferred NSAID in patients with low-moderate GI risk and high CV risk

Naproxen

Avoid in patients with both high GI and CV risk

Non-selective NSAIDs and COX-2 selectives

1st line NSAID ulcer treatment

PPI for 8 weeks & d/c NSAIDs

Alternative NSAID ulcer treatment

High dose H2RAs or sucralfate

Interacts with albumin and fibrinogen to form physical barrier over and open ulcer

Sucralfate (Carafate)

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