GERD/PUD - PUD
16 important questions on GERD/PUD - PUD
Mucosal erosion within the GI tract
Food effect on duodenal ulcers (from H. Pylori)
Food effect on gastric ulcers (from NSAIDs)
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H.pylori diagnostic test
Fecal antigen test to detect H.pylori in stool
When should PPIs, bismuth and abx be discontinued to avoid a false negative H.pylori test?
1st line for H. Pylori
BSS QID + metronidazole QID + tetracycline QID + PPI BID
When should bismuth quadruple therapy be used, aside from 1st line?
Previous macrolide exposure
PCN allergy
Failed triple therapy
H. Pylori treatment if low (<15%) local clarithromycin resistance rates, no previous macrolide exposure, but is preferred if previous macrolide exposure
Amox BID + clarithromycin BID + metronidazole BID + PPI BID
H. Pylori treatment if low (<15%) local clarithromycin resistance rates and no previous macrolide exposure
Amox BID + clarithromycin BID + PPI BID
OR
amox + clarithromycin + lansoprazole (Prevpac)
Combo to specifically reduce risk of NSAID induced ulcers
Secondary prevention of CV and cerebrovascular events in pt's at risk for aspirin induced ulcers
Preferred NSAID in patients with low-moderate GI risk and high CV risk
Avoid in patients with both high GI and CV risk
1st line NSAID ulcer treatment
Alternative NSAID ulcer treatment
Interacts with albumin and fibrinogen to form physical barrier over and open ulcer
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