Asthma - Drugs - Leukotriene modifying agents

11 important questions on Asthma - Drugs - Leukotriene modifying agents

What does montelukast inhibit?

Leukotriene D4 (LTD4)

What does zafirlukast inhibit?

LTD4 and LTE4

What does zileuton inhibit?

Leukotriene formation
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How do leukotriene receptor antagonists work?

Reduce airway edema, constriction and inflammation

Montelukast dosing for ages 1-5 years

4 mg daily in evening

Montelukast dosing for ages 6-14 years

5 mg daily in evening

Montelukast dosing for adults

10 mg daily in evening

How can montelukast granules be mixed?

In breast milk or formula
With spoonful of applesauce, carrots, rice, or ice cream
Use within 15 min and directly into mouth

Aside from asthma, what else is montelukast approved for?

Allergic rhinitis and exercise induced bronchoconstriction

How should zafirlukast be dispensed?

In original container to protect from light and moisture

How can zafirlukast affect theophylline?

Can increase theophylline levels

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