Non-sterile compounding - Excipients
20 important questions on Non-sterile compounding - Excipients
Allows the contents of a tablet to stick together while permitting the contents to be released once ingested. Can provide stability and strength.
What is used to bulk up/add size to a very small amount?
In liquids, what is the purpose of diluents?
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Liquid examples of diluents. & fillers
Topical examples of diluents & fillers
Mineral oil
Lanolin
What facilitates the breakup of a tablet after PO administration because PO products have to be dissolved in order to be absorbed in the small intestine?
What prevents ingredients from sticking to each other and to equipment. Also improve powder flowability by reducing interparticle friction?
What prevents or slows microorganism growth, are required in most preparations (except in: sterile, used immediately, single-use packaging) BUT cannot be used in neonates?
Povidone iodine
Sodiumm benzoate/benzoic acid, benzalkonium chloride, benzyol alcohol
Sorbic acid/potassium sorbate
Methyl/ethyl/propyl parabens
EDTA
Thimerosal
Cetylpyridinium chloride
What keeps the pH within a certain range to improve stability and solubility & decrease irritation to sensitive tissues in the body?
What compounds are more polar, which makes them more water-soluble?
What equation calculates the pH of a buffer system?
Examples of buffers used to maintain acidic pH
Acetic acid/sodium acetate
Citric acid/sodium citrate
Examples of buffers used to maintain alkaline pH
Boric acid/sodium borate
Sodium bicarb/sodium carbonate
Keeps powders dry & prevent hydrolysis
Break up and inhibit the formation of foams
Prevent degredation due to oxygen, light & moisture, and mask bad taste
What type of coating prevents drug degredation in the stomach for drugs that can be destroyed by stomach acid?
Increase the viscosity of a substance & stabilize the mixture
What gelling (thickening) agents are commonly used and swell when mixed with water?
When put into emollients, it draws water into the skin to moisturize skin. It prevents preparations from becoming dry and brittle.
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