Asthma - Drugs - Theophylline

5 important questions on Asthma - Drugs - Theophylline

How does theophylline work?

Blocks phosphodiesterase, to INCREASE cyclic adenosine monophosphate (cAMP), resulting in bronchodilation

PO theophylline loading dose

5 mg/kg IBW
(or TBW if <IBW) 

Theophylline therapeutic range

5-15 mcg/mL
Measure peak level at steady state, after 3 days of PO dosing
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Theophylline toxicity side effects

Persistent vomiting, arrhythmias, seizures

What can theophylline do to lithium levels?

Decrease lithium

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