Opioid Overdose
3 important questions on Opioid Overdose
Investigations and monitoring for Opioid Overdose
Investigation :
1. To confirm, UDT can report positive content within 24H use
2. To monitor symptom of withdrawal – Clinical Opioid Withdrawal Scale or Subjective Opioid withdrawal scale
1. To confirm, UDT can report positive content within 24H use
2. To monitor symptom of withdrawal – Clinical Opioid Withdrawal Scale or Subjective Opioid withdrawal scale
Immediate management for Opioid Intoxication
· Naloxone should be administered
· Dosing of naloxone:
o typically 0.05 to 0.1 mg intravenously,
o Repeat doses of 2 mg may be required every 3 to 4 minutes for a total of 10 mg.
· Activated charcoal may be used to decontaminate the gastrointestinal tract in cases of oral opiate overdose, which can be given up to 2 to 3 hours after ingestion.
· Most patients who overdose on opiates and experience a reversal with naloxone are admitted for observation for at least 12 to 24 hours.
· Dosing of naloxone:
o typically 0.05 to 0.1 mg intravenously,
o Repeat doses of 2 mg may be required every 3 to 4 minutes for a total of 10 mg.
· Activated charcoal may be used to decontaminate the gastrointestinal tract in cases of oral opiate overdose, which can be given up to 2 to 3 hours after ingestion.
· Most patients who overdose on opiates and experience a reversal with naloxone are admitted for observation for at least 12 to 24 hours.
Pharmacological approach for relapse prevention for opioid use
Long term plan
1. Methandone replacement therapy
2. Suboxone
3. Naltrexone
1. Methandone replacement therapy
2. Suboxone
3. Naltrexone
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