Smoking and Vaping
5 important questions on Smoking and Vaping
Addictive property of Nicotine
Rapid effect (Only less than 10 seconds is required to reach the brain, faster than IV route)
Prolonged withdrawal (>40% of withdrawal symptoms lasts more than 3 weeks) Easy availability
Non-intoxicating
Public Health issue with smoking
It is the main risk factors for many non-communicable diseases
It causes damage to the environment and is a cause of financial burden
Rationale for Pharmacotherapy in Nicotine Addiction
Manage the negative mood states
Provide opportunity to alter behaviour without withdrawal
Reduce withdrawal symptoms
Reduce weight gain
Reduce smoking craving
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
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Nicotine Replacement Therapy
Formulations available:
- Gum (2mg, 4mg preparation) – 2mg is for those who smokers less than 20 cigarettes/day, 4mg is for those who smoke more than 20 cigarettes/day, should not exceed 60mg/day
- Patch (5mg, 10mg, 15mg, 25mg (indicated if smoke more than 15 cigarettes/day) preparation) 16-hour patch over a 12-week program
- Inhaler (10mg) – Discontinued
- Lozenge (2mg, 4mg) – Not available at the present time
- Microtab
Common side effects: Headache, nausea, dizziness, jaw-ache and sore mouth/throat (gum), transient local skin reaction (patch)
Non Nicotine Pharmacotherapy (pill cessation) for smoking
MOA: reduces the ability of nicotine to bind and stimulate the mesolimbic dopamine system
b. Bupropion (Zyban) and Nortriptyline
Antidepressants for smoking cessation Mode of action is independent of their antidepressant effect
Similar efficacy to nicotine replacement
c. Naltrexone
Not first line treatment, useful if presence of comorbid alcohol addiction
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
