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• 1 Hoorcollege 1 - Overview

• 1.1 Drug discovery and development pipeline

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• Wat is het doel van lead finding/discovery?

  Een molecuul vinden dat "iets" doet met de target (=lead), zoals binding, activatie of repressie.

• What are the methods in lead finding?

  -High-throughput screening (HTS) (hoe bind molecuul aan target)
  -Virtual screening (docking, pharmacophore modeling, novo design)
  -Combinatorial chemistry (veel chemische moleculen tegelijk maken)
  -Molecular dynamics (MD) (computersimulatie beweging atomen)
  -Natuurlijke producten screenen
  -Cheminformatics.

• What are the two subtopics under Rational/Structure based design in Lead Optimization?

  Homology modeling and Molecular modeling.

• What is the other method in Lead Optimization mentioned?

  Quantitative Structure-Activity Relationship (QSAR, kijk naar structuur molecuul en activiteit)

• 1.2 Drugs and drug targets

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• What usually results from binding interactions in drug targets?

  Binding interactions usually result in an induced fit where the binding site changes shape to accommodate the drug.

• What may the induced fit alter in drug targets?

  The induced fit may also alter the overall shape of the drug target.

• 1.3 Protein structure and function

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• What does the tertiary structure of proteins maximize and minimize?

  The tertiary structure of proteins maximizes favorable interactions and minimizes repulsive interactions.

• 1.4 Enzymes: structure and function

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• What effect do enzymes have on reactions?

  They lower the activation energy and speed up time to reach equilibrium. (Het zijn de katalysatoren van het lichaam)

• How does binding affect the enzyme?

  Binding alters the shape of the enzyme (induced fit)

• What is a reversible inhibitor?

  A reversible inhibitor is a type of enzyme inhibitor that can bind to and dissociate from the enzyme.