Animal research
10 important questions on Animal research
What kind of research questions are mainly answered with animal research? (3)
- Basal questions; before going into translational and clinical research.
- Testing a new drug => effectiveness
- Testing a new drug => safety testing
When are you allowed to use animals for your research?
2) expected benefits outweigh potential risks
3) scientific objectives cannot be achieved using non-animal methods
What is the history of animal law?
1977: Dutch law on animal welfare
1986: European law on animal welfare
2010-current: revised and strict Eu
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What are animal experiments; by law?
- Vertebrates and chephalopods =>inktvissen
- Risk of discomfort
- Which may cause the animal a level of pain, suffering, distress or lasting harm equivalent to, or higher than, that caused by the introduction of a needle in accordance with good veterinary practice.
- A known or unkown outcome
- Scientific purpose as described in EU Directive 2010/63
Is testing cosmetics and sunscreen an animal experiment?
Testing the effect of a new sunscreen on the skin of pigs
Where can you find what procedures you have to follow? And what do you need for your research?
=> clear research question
If you develop a new drug, do you need animals?
What are the levels of discomfort? And why is this important?
- Non recovery = performed entirely under general anaesthesia. and is humanely killed without regaining consciousness
- Mild = short-term mild pain, suffering or distress + no significant impairment of the well-being
- Moderate = short-term or long term moderate pain, suffering or distress + Moderate impairment of the well-being
- Severe = severe pain, suffering or distress, or long- lasting moderate pain, suffering or distress • Severe impairment of the well-being
What is the level of severity when: you don’t know the cause of death?
In practice; how to come to the 3R's?
- Fasten/accelerate the development of new models and tools based on the latest science and technologies => support new ideas in all ways
- Carefully look at study designs so that you don't have to do it again and that it really adds something to the field => so you reduce the number of animals
- Improve animal welfare by the latest technologies.
- Improve understanding of welfare
The question on the page originate from the summary of the following study material:
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