Study designs

9 important questions on Study designs

Percentage research performed on white males/ male animals?

70%

So, observational studies. Ecological, cohort, cross sectional. What are the pros and cons of ecological studies?

  • Easy
  • Large population
  • association on population level


  • no control over confounders
  • no temporality
  • ecological fallacy?

So, observational studies. Ecological, cohort, cross sectional. What are the pros and cons of cohort studies?

  • Individual analysis => easier to  see confounders
  • Temporal relation


  • smaller sample size compared to ecological
  • more expensive then ecological
  • selection bias?
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So, observational studies. Ecological, cohort, cross sectional. What are the pros and cons of cross sectional studies?

Pro:
  • quick
  • multiple outcomes simultaneously
  • prevalence at a certain time
  • hypothesis generation possible


Con
  • not for rare diseases
  • selection bias and confounding
  • no temporal relation

Another observational study are case reports. Pro and cons.

Pro
  • Rare diseases
  • hypothesis generation is possible
  • Easy to conduct
Con
  • No causality
  • Not generalisable
  • publication bias 

Pros and cons of case control studies.

Pro
  • Rare diseases
  • Fewer participants
  • multiple exposures for one outcome

Con
  • potential risk for selection bias
  • recall bias
  • no incidence or prevalence 

What are pragmatic trials?

Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice conditions

Which three types of survey do exist?

  • Exploratory: what, how, why, open vragen
  • Descriptive: what, how, when, who, gesloten vragen
  • Explantory: why, highly structured vragen. TEST HYPOTHESIS

Pros and cons for survey?

Con:
Social desirability bias => self report bias
Difficult to reach certain populations => laag geletterden.
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