Tissue engineering
5 important questions on Tissue engineering
Learning goals of tissue engineering.
- Understanding the basics of tissue engineering (TE)
- Discussing various methodologies on TE and ask research questions
- Understanding the strengths and limitations of preclinical research and tissue engineering
Take home messages
• Select the appropriate research question and methodology
• Preclinical study design should be translatable
• Consider conditions mimicking target tissue and disease model
• Each design has its advantages and disadvantages
• Collaborate with experts in the other field
Describe the cycle of tissue engineering. What is needed?
- You take cells from the patient
- You cultivate this into 2D
- You seed it into a 3D scaffold
- You add => growth factors, small molecules, nanoparticles, cells
- Tissue will organize itself
- Transplantation
What is the problem with the permenant implants for the prolapse?
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What are important secondary outcome variables?
- What are the cell−implant interactions
- How does the immune system react
What are strenghts of tissue engineering?
- Personalized medicine (generate from the tissue of the patient itself)
- Reduced rejection risk (compared to donor tissue)
- Overcoming donor shortages
- Regenerative potential (sustainable solution)
- Reduced animal testing
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