2016 Midterm, Koch & Robertson

24 important questions on 2016 Midterm, Koch & Robertson

Which statement DEFINES a genetic mutation?

An uncorrected mistake in DNA replication, which alter the DNA sequence

In which state will the chromatin be condensed (heterochromatinized) and DNA unreadable leading to a state of transcriptional silence?

Histone is deacetylated and DNA is methylated

Which statement is TRUE for the inheritance pattern of a monogenic Autosomal Dominant Trait?

The recurrence risk of each offspring of an affected parent is 100%
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Which statement is TRUE for teh inheritance pattern of a monogenic X-linked dominant trait?

All sons of an affected male and a normal female are normal

Which statement is TRUE for a polygenic inheritance trait?

Affected traits are variably expressed and can be influenced by the environment

What phenomena are mutations in neural crest cells often associated with?

Pleiotropy

The karyotype Figure 1 (cattle) is described as

None of the above

The abnormality in Figure 1 (cattle) is described as:

Trisomy

The animal Figure 1 (cattle) is expected to present with

Infertility

The owner of the animal Figure 1 (cattle) would be advised to

Cull

Nutrigenomics is the branch of science that

Examines the response of genes to food compounds

Which of the following statement is false?

Influence of caffeine on bone mass may not depend on specific genes

For gene manipulation which tool helps us to cut the DNA at the site of interest?

DNA restriction endonuclease enzymes

For a normal cell in a dog to become a cancer cell then the cell must acquire characteristics (capabilities) which could include (choose one)

Genomic instability

A 3 year old male Greyhound presents with a mass on his leg. The astute clinician performs a biopsy and diagnoses cancer. The mass in this dog has increased in size because, in contrast to normal cells, hthe neoplastic cells (choose ONE)

Have a larger proportion of cells proliferating

Beef cattle show better maternal behaviour than dairy cattle - which of the following is the suggested mechanism?

Artificial selection for milk production in dairy cattle

Which of the following is a common effect of domestication on behaviour:

None of the above

Which statement is TRUE for molecular diagnostic tests of nucleic acid?

Polymerase chain reaction (PCR) can test for DNA/RNA

Which statement is TRUE for infectious disease DNA tests?

All of the above

Multimodal administration of cells refer to

The combination of cells with other biologics or drugs

In order to evaluate the efficacy of stem cell therapies studies need to account for

All of the above

Multipotent mesenchymal stromal cells may exert their function by

Mechanisms described in answer B and D (differentiation into the cell type of the injured tissue and become a functional part of the tissue, alter the function of the immune system at the repair site through cell-cell contact and secreted factors)

Embryonic stem cells can be generated from living individuals

False

Lavender foal syndrome is due to a mutation in the following gene

MYO5A gene

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