Bipolar Mood Disorder

7 important questions on Bipolar Mood Disorder

Overlapping features of BPD and BMD

Affective lability
Disproportionate
Suicidality
Risky behaviour
Impulsivity
Delusion

Bipolarity Characters in MDD (Compared to Pure MDD)

● Earlier age of onset of depression.
● More depressive episodes over lifetime.
● More comorbidity with:
○ Anxiety disorders
○ Substance use disorders
○ Impulse control disorders
● Higher risk of suicide attempts (though lower than bipolar II).

Diagnostic Criteria for BMD with mixed features and rapid cycling

BMD with the presence of at least 3 symptoms suggestive of the current episode.
ie : Present of Depressive symptoms during hypomanic/manic phase
and vice versa

Rapid Cycling
The presence of at least 4 major mood episode in one year
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Strategy to treat rapid cycling BMD

1. Withdraw AD
2. Evaluate possible precipitants - Manage accordingly
3. Optimize mood stabilizers, consider combine mood stabilizer (Lithium + Epilim, Lithium + Lamotrigine, Epilim + Carbamazepine)
4. Consider adjuncts
Aripiprazole (15-30mg/D)
Olanzapine (10-20mg/D)
Quetiapine (300-600mg /D)

Prognosis or BMD with Mixed features and Rapid Cycling

Rapid Cycling: Associated with a more chronic course, higher relapse rates, and greater treatment resistance.


Mixed Features: Can lead to more severe mood instability and higher functional impairment compared to typical manic or depressive episodes.

Psychosocial intervention for BMD

According to CANMAT 2023
1st line : Psychoeducation
2nd line : CBT and Family Focus Therapy
3rd line : IPSRT

IPSRT in Bipolar Mood DIsorder

biopsychosocial treatment approach designed specifically for individuals with bipolar disorder
It operates on the theory that instability is fundamental to the illness and that disruptions in daily routines lead to biological rhythm disturbances that trigger mood episodes

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