Summary: Genomics For Health And Development
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Introduction Genomics
This is a preview. There are 38 more flashcards available for chapter 01/09/2025
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What is Moore's law?
The observation that the number of transistors on computer chips doubles approximately every two years. -
What would happen if genomic DNA sequences were composed of random nucleotides?
All 17-mers would be present once or not at all in any genome. -
What is the chance of detecting an A in a random DNA sequence?
1/4 -
What is the chance of detecting a 17-mer sequence?
(¼)^17 = 1.72x10^10. -
What is more complex to sequence, the natural genome or random DNA sequences?
The natural genome, because there are repetative sequences and it's highly structured. -
What is vertical coverage?
The average number of reads that cover each nucleotide in the assembly. -
What is the horizontal coverage?
The percentage of the target genome that has been (re)covered in the assembly. -
What can you detect with metabolomics?
The reality of the system, which includes effects of post-translational regulation of protein activity. -
What advantage does transciptomics have over proteomics?
Nucleic acids are easier to track and they can be amplified. -
What molecule transcribes DNA into RNA?
RNA polymerase II
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