Book summary - overview of human genetic variation - DNA -repair
3 important questions on Book summary - overview of human genetic variation - DNA -repair
Base mismatch repair?
- The nick on a new replicated lagging DNA strand is for mismatch repair the clue to know which strand is the correct one.
Homologous recombination mediated DNA repair
strand break.
- Double strand break
- Trimming back the 5'ends to create a 3' and overhang
- Strand invasion
- DNA synthesis and ligate the ends
- Resolution is the incorporation of the correct nucleotides during DNA synthesis because template from sister chromatid is used
Nonhomologous end-joining (NHEJ)?
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