Neuroanatomy - Special Senses

70 important questions on Neuroanatomy - Special Senses

What forms the olfactory epithelium in the nasal cavity?

10-100 millions of olfactory receptors with supporting cells

What type of neurons are olfactory receptors?

Bipolar neurons

What is the first order neuron in the olfactory pathway?

Olfactory receptors
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Where are the dendrites of olfactory receptors located?

In the nasal cavity

What and where do the axons of all olfactory receptor neurons collectively form?

Axons of olfactory receptors project through cribriform plate forming left and right olfactory nerves

Where do olfactory receptors synapse with second order neurons?

Axons of olfactory receptors terminate and synapse with second order neurons in the olfactory bulb

What are mitral cells?

Second order neurons in the olfactory pathway

What do axons of mitral cells form?

Olfactory tract

How does the olfactory tract reach the cortex?

The olfactory tract synapses directly with the cortex without going through the thalamus

What is the function of the primary olfactory cortex?

Conscious awareness of smells

What is the function of the association olfactory area?

Putting olfactory information into context

What does the primary olfactory cortex and the association olfactory area form?

Piriform cortex

How does the piriform cortex signal other brain areas?

Either directly or via entorhinal cortex

Which area of the brain does the primary olfactory cortex synapse with for odour identification and discrimination?

Primary olfactory cortex travels through the thalamus to the orbitofrontal cortex for odour identification and discrimination between 10,000 smells

Which area of the brain does the primary olfactory cortex project to for odour-evoked emotional response?

Amygdala

Why does the primary olfactory/piriform cortex signal the hippocampus via entorhinal cortex?

For odour-evoked memory

What is the function of the gustatory pathway?

Relays information about taste

Where are 10,000 taste buds distributed?

Tongue, soft palate, pharynx, epiglottis

How does the number of taste buds change with age?

Declines with age

How many gustatory receptor cells are in each taste buds on average?

50 gustatory receptor cells

What are the three organisations of taste buds and where are they located?

1. Vallate papillae - back of tongue
2. Fungiform papillae - all over tongue
3. Foliate papillae - side of tongue

Which papillae degenerates in early childhood?

Foliate papillae

What are the 3 cranial nerves involved in the gustatory pathway and where do each of them innervate?

1. Facial (CN VII) - anterior 2/3 of tongue
2. Glossopharyngeal (CN IX) - posterior 1/3 of tongue
3. Vagus (CN X) - soft palate, pharynx, and epiglottis

Where do the first-order neurons of the gustatory pathway originate?

From taste receptors

Where do the first-order axons of the gustatory pathway synapse?

In the gustatory nucleus

Where is the gustatory nucleus?

In the nuclei of solitary tract in the medulla oblongata

Where do the second-order neurons of the gustatory pathway project to?

They project from the gustatory nucleus to the thalamus (specifically the ventral posteromedial nucleus).

What is the function of the third-order neurons in the gustatory pathway?

They project from the thalamus to the primary gustatory cortex for conscious taste perception.

What is the function of the primary gustatory cortex projecting to the orbitofrontal cortex?

Flavour identification and discrimination

What does the projection of the primary gustatory cortex to the hypothalamus and amygdala do?

Taste-evoked emotion

What does the projection of the primary gustatory cortex to the hippocampus do?

Taste-evoked memory

What are the receptors that are excited by light in the visual pathway?

Photoreceptors, which are rods and cones

What is the 1st order neuron that cones and rods signal?

Retinal bipolar cells

What is the 2nd order neuron that retinal bipolar cells excite?

Retinal ganglion cells

What do axons of retinal ganglion cells form?

Optic nerve (CN II)

Where are third order neurons of the visual pathway located?

In the lateral geniculate nucleus (LGN), which is in the thalamus

Explain the pathway of 2nd order neurons of the visual pathway to the lateral geniculate nucleus (LGN).

1. Axons of retinal ganglion cells form optic nerve (CN II)
2. Axons from lateral side of the retina ipsilaterally through optic chiasm, axons from medial side of the retina decussate at optic chiasm
3. Axons continue travelling through optic tract
4. Most axons terminate at lateral geniculate nucleus (LGN) in thalamus. Some 2nd order neuron collaterals project to the superior colliculus or pre-tectal nucleus (both in midbrain).

What is the function of 2nd order neuron collaterals in the visual pathway that project to the superior colliculus?

Controls extrinsic eye muscles for tracking

What is the function of 2nd order neuron collaterals in the visual pathway that project to the pre-tectal nucleus?

Pupillary control

Explain how the 3rd order neuron synapses with the visual cortex

1. 3rd order neurons form optic radiations
2. 3rd order neurons travel through optic radiations to terminate at visual cortex

Which portion of the retina processes the lateral portion of visual field?

Medial retina

Which portion of the retina processes the medial portion of the visual field?

Lateral retina

What would a lesion in one of the optic nerves (marked as 1) result in?

Monocular blindness = blindness of both medial and lateral visual field in one eye that is ipsilateral to lesion

What would a lesion in the part of the optic nerve (marked as 2) that relays information from the lateral retina result in?

Loss of medial visual field in the eye that is ipsilateral to lesion

What would a lesion in the optic chiasma (marked as 3) results in?

Bitemporal hemianopia = Loss of lateral visual fields in both eyes because relaying of information from medial retina is disturbed

What would a lesion in the optic tract (marked as 4) result in?

Homonymous hemianopia = Loss of medial visual field in the ipsilateral eye to the lesion + Loss of lateral visual field in the contralateral eye to the lesion

What would a lesion in the optic radiations result in (marked as 5)?

Homonymous hemianopia = Loss of medial visual field in ipsilateral eye to lesion + Loss of lateral visual field in contralateral eye to lesion

Which pathways have their first order neurons in the vestibulocochlear nerve (CN VIII)?

Both the auditory and equilibrium pathways

What are the two branches of vestibulcochlear nerve (CN VIII) and what are each of their functions?

1. Cochlear nerve - relays auditory information
2. Vestibular nerve - relays information about position and movement of head

Where are the receptors of the auditory pathway located?

In the cochlea

How do 1st order neurons of the auditory pathway synapse with 2nd order neurons?

1. Cell bodies of 1st order neurons in cochlea form spiral ganglion of CN VIII (vestibulocochlear)
2. Axons of 1st order neurons form the cochlear branch of CN VIII
3. Cochlear branch of CN VIII synapse with two ipsilateral cochlear nuclei in medulla once it reaches the brainstem

Where do the contralateral axons of the 2nd order neuron project through and to?

Some axons of the 2nd order neuron contralaterally projects to the inferior colliculus of the midbrain via lateral lemniscus

Where do the bilateral axons of the 2nd order neuron project to?

Some axons of the 2nd order neuron bilaterally (both ipsilaterally and contralaterally) projects to the superior olivary nucleus of the pons

What is the purpose of superior olivary nucleus in the auditory pathway?

The difference in timing between the two sides allow lateral sound localisation

How does the 2nd order neurons projecting to the superior olivary nucleus continue synapsing?

They continue as partial 3rd order neurons and continues ipsilaterally ascending their axons from the superior olivary nucleus to the inferior colliculus, forming the rest of lateral leminiscus

Where are the 4th order neurons of the auditory pathway located?

Located in inferior colliculus

How do 4th order neurons synapse with 5th order neurons of the auditory pathway?

4th order neuron axons ascend ipsilaterally to the medial nucleus of thalamus

Where does the 5th order neuron synapse to once it receives signals from the 4th order neuron?

Axons of the 5th order neuron ascend ipsilaterally to the primary auditory cortex

What is the result of a lesion in the auditory pathway above the cochlear nuclei?

Loss of acuity in both ears = difficulty in sound localisation

What is the main function of the equilibrium pathway?

Maintaining balance

Where are receptors of the equilibrium pathway located?

In the vestibular apparatus

Where does vestibular nuclei receive input from?

1. First order neurons of the equilibrium pathway
2. Eyes
3. Proprioceptors in skeletal muscles

Where is the cell body of the 1st order neurons of the equilibrium pathway located?

Located in vestibular ganglion of CN VIII (vestibulocochlear)

What do the axons of the 1st order neurons of the equilibrium pathway form?

Vestibular branch of CN VIII (vestibulocochlear)

Explain how the 1st order neuron continues synapsing in the equilibrium pathway.

1. Most 1st order neurons synapse in the four ipsilateral vestibular nuclei of the medulla oblongata and the pons (2nd order neuron)
2. Some directly synapse in the inferior cerebellar lobe

How do 2nd order neurons of the equilibrium pathway synapse with the cortex?

2nd order neurons contralaterally syanpses with the 3rd order neuron—ventral posterior nucleus of the thalamus—which projects to the cortex

What is the purpose of signalling extraocular muscles in the equilibrium pathway?

To control coupled movements of the head and eyes to maintain focus on visual field

How does the 2nd order neuron of the equilibrium pathway synapse with extraocular muscles?

From the vestibular nuclei, axons of 2nd order neurons ascend ipsilaterally and contralaterally to the motor nuclei of CN III, IV, VI (3rd order neurons) and continues ascending to extraocular muscles

What is the purpose of signalling the motor nuclei of accesory nerve and the vestibulospinal tract in the equilibrium pathway?

To coordinate body and head movement to maintain equilibrium

How do 2nd order neurons of the equilibrium pathway synapse with the motor nucleus of the accessory nerve and vestibulospinal tract?

Axons of 2nd order neurons descend to these areas.

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