Anti NMDR Encephalitis
3 important questions on Anti NMDR Encephalitis
'Redflags' to consider organic cause of psychosis
- Rapid Progression of Symptoms
- Concurrent Neurological Symptoms
- Psychiatric Treatment Resistance
- Unexplained autonomic instability (labile blood pressure, heart rate variability, or temperature instability) and central hypoventilation
- Other indicators include fluctuating catatonia, mutism, a fluctuating sensorium (level of consciousness), and severe insomnia
Define Anti NMDAR Encephalitis
Autoimmune disorder where antibody attack NMDA receptor causing psychiatry, neurology and autonomic instability
Investigation for Anti NMDAR Encephalitis
1. Lumbar Puncture
CSF - Detection of IgG antibody against NR1 Subunit of NMDA receptor
more sensitive than serum
2. EEG - Highly sensitive but not specific
3. Tumor Screening - mostly a paraneoplastic syndrome
4. PET Scan - More reliable as it may show metabolic abnormalities even with normal MRI
CSF - Detection of IgG antibody against NR1 Subunit of NMDA receptor
more sensitive than serum
2. EEG - Highly sensitive but not specific
3. Tumor Screening - mostly a paraneoplastic syndrome
4. PET Scan - More reliable as it may show metabolic abnormalities even with normal MRI
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