GIT - Proton pum inhibitors (PUD) - Anticholinergic (Muscarinic Antagonists)
7 important questions on GIT - Proton pum inhibitors (PUD) - Anticholinergic (Muscarinic Antagonists)
Why are anticholinergic agents less effective as acid suppressing drugs in PUD?
- Acetylcholine is not the final mediator of HCL secretion.
- No effect on HCL secretion mediated by histamine or gastrin.
- Large dose is required (leads to adverse effects).
- Decreases mucous more than HCL (decreased buffer capacity).
- Delay gastric emptying prolonging exposure of ulcer to HCL.
What are the pharmacological effects of anticholinergics?
- Decreases HCL secretion (mild effect)
- Antispasmodic
- Decreases nocturnal GI pain
What are some examples of Atropine-like substitutes?
- Hyoscine
- Dicyclomine
- Glycopyrrolate
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Why are anticholinergics given in combination with other anti-ulcer agents?
What is the function of Pirenzepine?
Why are anticholinergic drugs contraindicated in old males?
What is the recommended dose for Pirenzepine?
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