GIT - Proton pum inhibitors (PUD) - PUD Triple Therapy
12 important questions on GIT - Proton pum inhibitors (PUD) - PUD Triple Therapy
What are the causes of treatment failure?
- Low compliance
- Resistance of HP to antibiotics
- Resistance of Clarithromycin 7.8%
- Metronidazole 39.2%
What is the second line therapy for the eradication of H. pylori?
- Bismuth subsalicylate 525mg
- Tetracycline 500mg QID
- Metronidazole 400mg QID
- Esomeprazole 20mg BD
What is the composition of rescue therapy 3rd line in case of Rx failure?
- Twice daily 2 - 4 week course
- Rifabutin 150mg, Amoxicillin 1g, Esomeprazole 20mg
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What is the standard first line regimen summary for H. pylori eradication?
What is the eradication rate and cost consideration for the 3rd line rescue therapy?
- Eradication rate is 70%
- But expensive
What is the standard first line regimen for H. pylori eradication?
What are the components of the first option in triple therapy for H. pylori?
- Clarithromycin 500mg BD 2 weeks
- Metronidazole 400mg tid x 2/52 or Tinidazole 500mg bid x 2/52
- Lansoprazole 30mg or Esomeprazole/Omeprazole 20mg BD 2/52
What are the antibiotic options in the triple therapy for H. pylori?
- Clarithromycin 500mg BD 2 weeks
- Amoxicillin 1g BD /2 weeks
- Metronidazole 400mg tid x 2/52
- Tinidazole 500mg bid x 2/52
What are the components of the second option in triple therapy for H. pylori?
- Amoxicillin 1g BD /2 weeks
- Metronidazole 400mg tid x 2/52 or Tinidazole 500mg bid x 2/52
- Lansoprazole 30mg or Esomeprazole/Omeprazole 20mg BD 2/52
What PPIs are used in the triple therapy for H. pylori eradication?
- Lansoprazole 30mg
- Esomeprazole/Omeprazole 20mg BD 2/52
What is the note regarding the combination of antibiotics in triple therapy?
What is the note regarding the combination of antibiotics in H. pylori treatment?
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