Drug discovery and development

4 important questions on Drug discovery and development

Which receptors can be studied in Guinea-pig ileum?

ACh (muscarinic M(3)), histamine H(1) & H(3), neurokinin NK(1), bradykinin B(2), 5HT(3), CCK(A), CCK(B), Angiotensin AT(2

Which receptors are found in Mouse vas deferens?

mu-, kappa-, and delta-opioid receptors, and dopamine D(2

Which receptors are studied in the Rabbit heart (Langendorff)

beta(1)-adrenoceptors.
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Which receptors are examined in Rat or Rabbit aorta?

alpha(1)-adrenoceptors, 5HT(2), neurokinin NK(1), bradykinin B(1), angiotensin AT(1), CGRP(1).

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