Where is the immune system located in the animal's body? - Various cells of the Immune System

8 important questions on Where is the immune system located in the animal's body? - Various cells of the Immune System

What are the cells of the immune system?

Specialized WBCs form the innate immune system and the adaptive immune system

  1. T cell
  2. B cell
  3. Natural killer cell
  4. Monocyte
  5. Macrophage
  6. Neutrophil
  7. Eosinophil
  8. Basophil
  9. Mast Cell
  10. Dendritic Cell

What are cells involved in Innate response?

1. Macrophage
2. Granulocytes (Neutrophils, Eosinophils, Basophils)
3. Mast cells
4. Dendritic cells
5. Natural killer cells
6. Complement proteins

The two below are bridging cells that do both innate and adaptive responses
7. Gamma delta T cells
8. Natural killer T cells

What are cells involved in adaptive response?

1. B lymphocytes and their antibodies
2. T lymphocytes (CD4+ and CD8+)


The two below are bridging cells that do both innate and adaptive responses
3. Gamma delta T cells
4. Natural killer T cells
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What do T cells do?

They are effector cells, they remember and can kill infected/cancerous cells.

- Soldiers

What do Natural Killer cells do?

They can recognize specific cells based on their surface proteins, and if they do not have the specific surface proteins, they will attack. Also do degranulation against cancerous cells.

- Papers please

What do dendritic cells do?

They are detectors and antigen presenting cells that detect danger signals and release cytokines. They can change their own stage of development and become mature, they can start to migrate towards the naïve T and B cells and give instructions.

- Nanny

How do dendritic cells communicate with T cells?

They activate T cells via a 3 signal mechanism
  1. Signal 1: MHC-peptide + T cell receptor = specificity
  2. Signal 2: CD80/86 + CD28 = co-stimulation for DC maturation, also CD40 + CD40L causes IL-12 production
  3. Signal 3: IL-12 production = IFN-y production and T cell differentiation

How do dendritic cells detect antigens?

They constantly sample their environment using Toll-Like Receptors (TLR) and C-type lectins to recognize pathogens. They do this via phagocytosis, macropinocytosis, and receptor mediated endocytosis

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