Liver - Disorders and serum bile acids
3 important questions on Liver - Disorders and serum bile acids
What disorders lead to increases in serum bile acids?
1. Cholestasis: Obstruction of bile duct, causes bile acid accumulation in the liver and diffusion into blood
2. Reduced functional liver mass: Impairment of bile acid return through portal blood
3. Congenital/acquired vascular shunts: Portal blood bypassing liver
2. Reduced functional liver mass: Impairment of bile acid return through portal blood
3. Congenital/acquired vascular shunts: Portal blood bypassing liver
What are some canine portosystemic shunts?
1. Intrahepatic shunts: Some vessels will bypass hepatic sinusoids and go straight to hepatic vein, common in large dogs
2. Extrahepatic shunts: Vessel formation outside of liver, sending blood straight to hepatic vein, common in small dogs
2. Extrahepatic shunts: Vessel formation outside of liver, sending blood straight to hepatic vein, common in small dogs
What are the consequences of portosystemic shunts?
Jaundice, due to high bilirubin content from lack of hepatic sinusoid activity
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