Absorption of vitamins and minerals - Calcium
3 important questions on Absorption of vitamins and minerals - Calcium
What happens to most ingested Ca2+?
It is unabsorbed and excreted in the feces
How does Ca2+ diffuse?
Ca2+ does not diffuse well through tight junctions of the small intestine regardless of its concentration gradient. It can use TRPV 5 and 6, calcium channels
How can calcium diffuse through vitamin D?
1. In Ca2+ deficient diet, PTH secretion occurs and activates Vitamin D, causing more calcium channels to open.
2. In the cytoplasm, Ca2+ binds to a carrier molecule (calbindin) for transport. Vitamin D also increases the expression and activation of calbindin
3. Ca2+ is pumped out of duodenal enterocytes by primary and secondary active transport
2. In the cytoplasm, Ca2+ binds to a carrier molecule (calbindin) for transport. Vitamin D also increases the expression and activation of calbindin
3. Ca2+ is pumped out of duodenal enterocytes by primary and secondary active transport
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