Lecture title - GI movemenets - Simple stomach
6 important questions on Lecture title - GI movemenets - Simple stomach
What are the functional parts of the simple stomach?
2. Distal (distal body, antrum, pylorus)
What happens in the proximal region of the simple stomach?
- Innervated by ENS/PSNS (vagus), limited CNS input
- Vagus stimulation decreases motility in the proximal part of stomach via NO/VIP to increase distension
What happens in the distal region of the simple stomach?
- Innervated by ENS/PSNS (vagus)
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How is emptying of the stomach controlled?
Inhibition: duodenal factors via arrival of bolus to duodenum, it slows down the emptying of the stomach until all nutrients are absorbed
What are the duodenal feedback mechanisms?
1. ENS afferent cells send signalsto ENS interneurons: inhibit gastric emptying
2. Afferent neurons in vagus send signals to brainstem and spinal cord: decreases vagal input and increases sympathetic output to inhibit gastric emptying
3. Duodenal enteroendocrine cells secrete gut hormones into the bloodstream (E.g. Cholecystokinin, somatostatin) and inhibits gastric emptying
Difference between solid vs liquid food
Solid foods exit the stomach much slower (gone from stomach in 3-4 hours, longer for high fat meal)
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