Cecum and colon - Diarrhea
3 important questions on Cecum and colon - Diarrhea
Why is the frequency of defecation increased during diarrhea?
1. Irritation/inflammation of bowels: inflammatory mediators lead to increased motility and secretion
2. Larger volume of feces: mainly due to increased H2O content
2. Larger volume of feces: mainly due to increased H2O content
Why would water content increase in the feces?
1. Increase in the amount of ingested water
2. Water secreted by the glands of GI system
3. Water secreted/lost directly through mucosal epithelium
2. Water secreted by the glands of GI system
3. Water secreted/lost directly through mucosal epithelium
What is the difference between hypersecretory diarrhea and malabsorptive diarrea?
Hypersecretory: water is lost osmotically via apical Cl- and/or HCO3- channels opening via raised cAMP levels in crypt cells via toxins
Malabsorptive: water is not absorbed osmotically in apical membrane of small and large intestine
Malabsorptive: water is not absorbed osmotically in apical membrane of small and large intestine
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