Innate Adaptive Immunity - Antigennicity

3 important questions on Innate Adaptive Immunity - Antigennicity

What is antigenicity correlated with?

  1. Size of molecule
  2. Degree of foreignness: xenoantigen (diff species) > alloantigen (same species diff individual) > autoantigen (self)
  3. Chemical complexity
  4. stability
  5. shape
  6. degradability

How do antibodies and T cells detect antigens?

Antibodies: recognize proteins, polysaccharides, and lipids by binding their epitopes

T cells: recognize only protein derived epitopes (antigens that have been processed and presented to them)

How do penicillin allergies work?

Penicillin gets broken down into penicillanic acid and bind to inert proteins like albumin, creating an epitope (penicilloyl-protein complex) and induce acquired immune response and allergies.

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