Learning Goal - Cluster of Differentiation (CD)

3 important questions on Learning Goal - Cluster of Differentiation (CD)

What are CDs involved in cell adhesion in neutrophils?

B2 integrins, all share CD18 as the beta subunit, these all let the cell exit blood vessels and move towards infection sites
      1. CD11a/CD18 (LFA-1) = binds ICAM-1 on endothelial cells, important for adhesion during mobilization
      2. CD11b/CD18 (CR3) = adhesion and complement mediated phagocytosis
      3. CD11c/CD18 = similar role in monocytes and macrophages

What are CDs involved in opsonization in neutrophils?

CD32 (FcyRII) = binds the Fc portion of IgG, allows phagocytes to recognize antibody coated pathogens

What are CDs involved in complement receptors?

1. CD11b/CD18 (CR3) = binds iC3b, strongly promotes phagocytosis via complement
2. CD35 (CR1) = binds C3b, important for immune complex clearance and phagocytosis

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