Innate Immunity II-2 - NETosis and Cancer
4 important questions on Innate Immunity II-2 - NETosis and Cancer
What happens in excessive NETosis?
How can NETosis contribute to cancer?
How can NETosis contribute to cancer METASTASIS?
2. Circulating tumor cells (CTCs) can become trapped within circulating NETs and protected from immune cells, they are exposed to high levels of local neutrophil elastase, and other factors that support proliferation
3. NETs can prepare metastatic tumor sites by inhibiting immune surveillance by T cells and NK cells, releasing MMP-9 and serine proteases that promote angiogenesis via VEGF, modulating the extracellular matrix (ECM) to favor cancer growth, and recruiting inflammatory cytokines that attract even more neutrophils
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How can we stop NETosis during cancer?
Antibodies against TGF beta: activates the immune system and reduce fibrosis + and blocks the activation of N2 (pro-tumor neutrophils)
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