Innate Adaptive Immunity - Dendritic Cells: APCs
8 important questions on Innate Adaptive Immunity - Dendritic Cells: APCs
Why are dendritic cells so important?
Where do dendritic cells originate from?
- Myeloid lineage: they are classic dendritic cells from monocytes (cDCs)
- Lymphoid lineage: they are plasmacytoid dendritic cells (pDCs)
- They specialize in responding to viruses by producing large quantities of type I interferons (anti-viral)
What are the two types of cDCs?
2. cDC2: Produce IL-6 for Th2 differentiation and IL-23 for Th17 differentiation
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What can immature DCs do?
They can promote immunological tolerance via overreactive T cell apoptosis and anergy
How do immature DCs mature?
Where do DCs usually travel to?
When do dendritic cells mature?
What are molecules required to activate naive T cells / mature DCs?
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