Learning Goal - Different types of leukocytes - Neutrophils
5 important questions on Learning Goal - Different types of leukocytes - Neutrophils
How do neutrophils move from blood to tissue?
- DAMPs and PAMPs change endothelial cells and neutrophils protein expression by making them upregulate P-selectin and L selectin respectively.
- L-selectin + P-selectin = slows neutrophils and make them roll along the endothelium
- Platelets produce platelet activating factor that causes neutrophils to produce leukocyte function-associated antigen 1 (CD11a/CD18)
- LFA-1 binds to intercellular adhesion molecule-1 (ICAM-1; CD54) which causes neutrophils to adhere to endothelium = upregulation of even more adhesion
- Endothelial cells contract and neutrophils migrate tissue through interrupted endothelial lining and phagocytose microbes
How do neutrophils phagocytose microbes?
- Neutrophils follow chemoattractant gradients to locate microbes
- Adherence is enhanced through opsonization
- Opsonization: when a molecule binds to both bacteria and phagocytic cell to bring them closer
- antibodies and complement proteins are common opsonins
What is respiratory burst?
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Which effector cytokines are released by neutrophils?
What are neutrophil extracellular traps (NETs)
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