Learning Goal - PAMPs/DAMPs and Inflammation - Interleukin-6
3 important questions on Learning Goal - PAMPs/DAMPs and Inflammation - Interleukin-6
How does interleukin affect neutrophils?
Neutrophils come first, then macrophages come later in inflammation, IL-6 regulates this transition
What are the functions of interleukin-6
- Activation of T cells, stimulation of Th2 responses, activation of Th17 cells, suppression of Treg cells, enhanced cytotoxicity
- Activation of hepatocytes, acute-phase response
- Affects brain, fever induction
- Activation of B cells, enhances IgA production (antibodies)
How does interleukin influence macrophage's takeover?
IL-6 and sIL-6Ra (soluble IL-6 receptor) in inflammatory fluids shift chemoattractant profile from neutrophil attracting factors (e.g. IL-8) to monocyte attracting factors such as MCP-1.
IL-6 and its receptor promotes neutrophil death and recruitment of macrophages
IL-6 also promotes macrophages to decrease production of pro-inflammatory cytokines (e.g. IL-1b) while promoting anti-inflammatory cytokine production
IL-6 and its receptor promotes neutrophil death and recruitment of macrophages
IL-6 also promotes macrophages to decrease production of pro-inflammatory cytokines (e.g. IL-1b) while promoting anti-inflammatory cytokine production
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