Innate Immunity III - Macrophages - M1 vs M2
3 important questions on Innate Immunity III - Macrophages - M1 vs M2
What is the difference between M1 and M2 macrophages?
M1: pro-inflammatory and microbial
M2: anti-inflammatory, pro-angiogenic, involved in tissue repair
M2: anti-inflammatory, pro-angiogenic, involved in tissue repair
How can M1 cells be identified in rodents, cattle, sheep, horses?
M1 cells can use nitric oxide synthase to convert arginine into anti microbial ROS
What causes macrophages to differentiate?
IFN-y promote macrophages to become M1
IL-4 promote macrophages to become M2
- M1 cells can also switch to M2 to help with tissue repair towards the end of inflammation (via IL-4, IL-10, IL-14)
IL-4 promote macrophages to become M2
- M1 cells can also switch to M2 to help with tissue repair towards the end of inflammation (via IL-4, IL-10, IL-14)
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