Innate Immunity III - Macrophages - Tissue Repair

3 important questions on Innate Immunity III - Macrophages - Tissue Repair

How do macrophages enhance tissue repair?

They initially release molecules that break down tissues to remove dead and dying cells, then release molecules that promote tissue remodelling

What are some tissue breakdown substances?

Tissue breakdown substances include:
  • Plasminogen activator
  • Proteases (e.g. MMP-9)
  • Collagenases
  • Elastases

What are some tissue repair substances?

Tissue repair substances include:
  • Fibroblast growth factors
  • Fibronectin
  • Angiogenic factors (VEGF)
  • Regulate extracellular matrix
  • TGF-beta
  • Protease inhibitors

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