Innate Immunity II-2 - Density of cells

4 important questions on Innate Immunity II-2 - Density of cells

What happens to the number of neutrophils during infection?

We will see the bone marrow releasing more immature neutrophils to compensate for high mobilization and death of neutrophils circulating.

What are the two types of neutrophils density-wise?

There are NDNs and LDNs

NDNs (normal-density neutrophils): standard, mature segmented neutrophils found in bottom layers)

LDNs (low-density neutrophils): lighter, immature neutrophils from emergency granulopoiesis foudn in top/middle layers

What are the two types of neutrophils function-wise?

There are N1 and N2 neutrophils

N1 (anti-tumor): They are from high-normal density nucleus neutrophils, produce TNF-a and interferons

N2 (pro-tumor): They are from low lobulated nucleus neutrophils, perform NETosis
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How does anti-tumour neutrophil polarization work?

Neutrophils (N1) can influence naive CD4+ Helper T cells into producing IFN-y producing Th1 cells & can influence naive CD8+ cells for anti tumour activities

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