Learning Goal - Common PRRs
3 important questions on Learning Goal - Common PRRs
What are some PRRs commonly found on sentinel cells throughout the body?
- Toll like receptors (TLRs): both intra and extracellular
- NOD like receptors (NLRs): cytoplasmic
- Retinoic acid-inducible gene-I (RIG-I) like receptors (RLRs): intra
- Receptor for advanced glycation end products (RAGE)
- Triggering receptors expressed on myeloid cells (TREMs)
What is a way that PRRs can allude the nature of the pathogen to the immune system?
The location of DAMPs/PAMPs binding to PRRs (intra vs extracellular)
What is the difference between intracellular and extracellular TLRs?
- Intracellular: optimized to bind viral and bacterial nucleic acid
- Extracellular: optimized to bind bacterial molecules
- Extracellular: optimized to bind bacterial molecules
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