B cells and Antibodies - B cells - BCRs and antibodies

10 important questions on B cells and Antibodies - B cells - BCRs and antibodies

What do B cells need to produce a strong antibody response?

1. Antigen binding
2. Stimulation PRRs
3. Cytokines
4. Helper CD4+ T cells
5. Complement

What are the two types of BCRs?

IgD and IgM

What makes BCRs different from antibodies

1. They have transmembrane proteins (membrane bound)
2. They bind to specific antigens to activate the B cell
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What makes antibodies different from BCRs?

1. They are secreted immunoglobulins (no transmembrane domains)
2. They counteract a specific antigen 
3. They bind to specific antigens to elicit immune responses through complement pathway and can recruit other immune cells to destroy pathogens

What are the five types of antibodies?

1. IgG: predominant Ig in serum for systemic defense
2. IgM: very large Ig produced during primary immune response
3. IgA: Ig responsible for defense of mucosal surfaces
4. IgE: Ig responsible for immunity to parasitic worms and allergies, found in very small quantities   
5. IgD: Ig found on the surface of immature lymphcoytes

Which antibody is stronger at the second exposure of the same antigen?

IgG is stronger than IgM

Which antibody is stronger at the first exposure of the same antigen?

IgM is stronger than IgG

Which immunoglobulin has the longest half life?

IgG

Which immunoglobulin has the highest complement-fixing capacity?

IgM

Which immunoglobulin has the highest anaphylactic (type I) hypersensitivity?

IgE

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