B cells and Antibodies - T dependent vs T independent antibody responses
5 important questions on B cells and Antibodies - T dependent vs T independent antibody responses
Why would CD4+ Helper T cells be needed in antibody responses?
Why would CD4+ Helper T cells NOT be needed in antibody responses?
What is characteristic of T cell independent antibody responses?
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How does T cell dependent antibody response occur?
2. B cell is activated via soluble antigen binding to BCR, antigen is internalized and displayed on MHC class II on their surface
3. Th2's CD40L and CD28 binds to B cell's CD40 and CD86, releases various cytokines that enhance antibody response
What cytokines are released by Th2 cells during T cell dependent antibody response?
- IL-4 & IL-13 → B cell activation and proliferation
- IL-5 → enhances antibody production (especially IgA)
- IL-6 → promotes differentiation into plasma cells
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