B cells and Antibodies - T dependent vs T independent antibody responses

5 important questions on B cells and Antibodies - T dependent vs T independent antibody responses

Why would CD4+ Helper T cells be needed in antibody responses?

With protein antigens, CD4+ T helper T cells aid in strong Ab responses

Why would CD4+ Helper T cells NOT be needed in antibody responses?

With polysaccharide, lipids, and other non protein antigens, CD4+ Helper T cells are not needed as they stimulate antibody production easily.

What is characteristic of T cell independent antibody responses?

There is no immunoglobulin switch or immunological memory, thus they cannot trigger a secondary antibody response
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How does T cell dependent antibody response occur?

1. DC activates CD4+ Helper T cell via MHC class II, releases IL-1 for Th2 phenotype
2.  B cell is activated via soluble antigen binding to BCR, antigen is internalized and displayed on MHC class II on their surface
3. Th2's CD40L and CD28 binds to B cell's CD40 and CD86, releases various cytokines that enhance antibody response

What cytokines are released by Th2 cells during T cell dependent antibody response?

  1. IL-4 & IL-13 → B cell activation and proliferation
  2. IL-5 → enhances antibody production (especially IgA)
  3. IL-6 → promotes differentiation into plasma cells

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