Innate lymphoid cells - Innate Lymphoid Cells (ILCs)
3 important questions on Innate lymphoid cells - Innate Lymphoid Cells (ILCs)
Characteristics of Group 3 ILCs
- Innate counterpart of T helper cells (Th17/Th22 cells)
- Produce IL-17 and IL-22
- Key role in mucosal immunity and barrier integrity
- Produce IL-17 and IL-22
- Key role in mucosal immunity and barrier integrity
Mechanism of activation of ILC3
1. ILC3 produces 2 main cytokines (IL-22 and IL-17)
2. IL-17 neutrophil recruitment for fungal elimination
3. IL-22 epithelial cells to increase antibacterial peptide production and support barrier
2. IL-17 neutrophil recruitment for fungal elimination
3. IL-22 epithelial cells to increase antibacterial peptide production and support barrier
What are lymphoid tissue inducer (LTi) cells?
They are a subset of group 3 ILCs, and express transcription factor RORyt. They are essential for the development of lymph nodes and peyer's patches. They are active during embryonic life and early development
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