Lymphocytes - Natural killer cells - Surface receptors

4 important questions on Lymphocytes - Natural killer cells - Surface receptors

What are the types of surface receptors on NK cells?

- Activating = KILL
- Inhibitory = DON'T KILL

They are usually balanced, but they will follow the stronger signals

What are examples of activating receptors on NK cells?

- NKG2D
- MICA/MICB
- NKp46
- CD16

What are examples of inhibitory receptors on NK cells?

- Ly49
- CD158 (KIR)
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What are Natural Killer T cells?

They are lymphocytes that have markers characteristic of both NK and T cells
- They use an invariant T cell receptor to respond to antigens presented by a molecule called CD1d (specialized MHC class I molecule)
- Respond much quicker than conventional T cells
- Activated by glycolipid antigens, as opposed to only peptides

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