Article A - Lymphocytes - Trafficking of lymphocytes
3 important questions on Article A - Lymphocytes - Trafficking of lymphocytes
What determines whether a lymphocyte enters lymphoid vs non lymphoid tissues?
The markers they express
- Endothelial cells express CD34, which is a receptor for CD62L (L-selectin), expressed on Naive lymphocytes
- Endothelial cells express CD34, which is a receptor for CD62L (L-selectin), expressed on Naive lymphocytes
What are some markers relating to trafficking of lymphocytes?
- CCR7, receptor: summons lymphocytes to lymph nodes via CCL21 binding to it (found in naive T cells, B cells, mature DCs)
- CCR5, receptor: summons WBCs to inflammation sites
- CD25, receptor: high affinity receptor for IL-2 on activated T cells, drives clonal expansion
- CD62L, receptor: marker on naive T cells that mediates cell rolling and trafficking to lymphoid tissues (HEV)
- CD69, receptor: early T cell activation marker, promotes retention of T cells in lymph tissues
- CCR5, receptor: summons WBCs to inflammation sites
- CD25, receptor: high affinity receptor for IL-2 on activated T cells, drives clonal expansion
- CD62L, receptor: marker on naive T cells that mediates cell rolling and trafficking to lymphoid tissues (HEV)
- CD69, receptor: early T cell activation marker, promotes retention of T cells in lymph tissues
Where are lymphocytes mostly distributed?
Lymph nodes and spleen. Blood is only 2% of representation of total lymphocytes in the body, thus not representative.
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