Learning Goal - Soluble Lectins
3 important questions on Learning Goal - Soluble Lectins
What are soluble lectins?
They are non-enzymatic non-antibody proteins that bind to sugars and exist in body fluids and act as pattern recognition receptors for PAMPs and DAMPs
Where are soluble lectins produced?
- Liver: C-reactive proteins, serum amyloid proteins
- Lungs: Pulmonary surfactant proteins
- Bone marrow and lymphoid tissues: Selectins
- Spleen, heart, skeletal muscle and brain: sites of synthesis for tetranectin
- GI tract and skin: throughout various locations
What is an example of a soluble lectin pathway?
Ficolin and Mannose Binding Lectin complexes (soluble lectins on the bacteria allow for effective binding and opsonization of the natural antibodies, leading to phagocytosis)
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