Learning Goal - Branches of adaptive immune system

4 important questions on Learning Goal - Branches of adaptive immune system

What are the two branches of the adaptive immune system?

Cell mediated (T cells): intracellular invaders such as viruses

Humoral (B cells, antibodies, complement): extracellular invaders such as bacteria

Which cells are the major antibody presenting cells in adaptive immune system?

Dendritic cells, macrophages, B cells

How do B cells behave as APCs?

They capture antigens through BCRs, internalize them, process them, and present them on their surface receptors to activate CD4+ T helper cells.

This leads to the maturation of B cells into plasma cells and memory cells, and regulates development of memory CD4+ T cells.
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How is having diverse antigen binding receptors achieved?

Genetic rearrangement resulting in millions of distinct binding sites

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