General Principles of Pharmacology
18 important questions on General Principles of Pharmacology
List the non-receptor drug mechanisms
Mannitol
Bulk & lubricating laxatives
Bile acid binding resins
Metal chelators
Purine/pyrimidine or folic acid structural analogues
What do bile acid binding resins do?
What do metal chelators do?
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What are purine/pyrimidine or folic acid structural analogues?
What is the role of agonists?
What is the role of antagonists?
What are the three events that are altered by conformational change of the receptor due to the binding of the drug to the receptor?
2. Ion channel open probability
3. Enzyme activity
What are the direct effects of conformational change from formation of drug-receptor complex?
2. Drug acts as competitive inhibitor by binding to receptor to obstruct substrate access to enzyme active site
What are the indirect effects of conformational change from formation of drug-receptor complex?
2. Modulation of downstream events
What is the cause of side effects from drugs?
What should the affinity (Ka) for target receptors of a drug be greater than to reduce side effects?
What is the relationship between drug concentration (dose) and side effects?
List the factors to consider when prescribing medications
Underlying pathophysiology
Drugs with potentially useful action
Monitoring therapeutic response
Risks vs. Benefits
Communication with patient in making decision to treat
At which level do drugs act on living systems?
What are the four types of drug names
2. Code name - short alphanumeric identifier (ex: D-365)
3. Generic name - official name of drug
4. Trade/proprietary name - marketed name (one drug can have multiple trade names)
What is the key difference between generic and trade names of drugs?
What are the three variable factors in drug molecules?
2. Shape & charge (does it complement to the binding site on receptor?)
3. Chemistry (most drugs are weak acids or weak bases)
Which ionization form of drug molecules cross membranes more easily?
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