Psychopharmacology - Antipsychotic - Cariprazine

4 important questions on Psychopharmacology - Antipsychotic - Cariprazine

Pharmacodynamic (MOA) of Cariprazine

Partial D2 Agonist - act as a thermostat as in aripiprazole ; in a situation where dopamine are excessive, they will act as antagonist, but in a situation where the dopamine is less, they will prevent blockade
Partial D3 Agonist - 3-10 times more affinity to D2 Agonist
Partial 5HT1A Agonist - Antidepressive and anxiolytic effect
Partial 5HT2B Antagonist - has high affinity, but yet still under study
Partial 5HT2A Antagonist - less likely to have EPS

FDA Approved indication use of Cariprazine

Schizophrenia - (3-6mg daily)
Bipolar Mood disorder type 1
Manic - 3-6mgdaily
Depress - 1.5mg-3mg daily
Adjunct to Major Depressive Disorder - 1.5mg to 3 mg daily

Pharmacokinetic (ADME) of Cariprazine

Strong CYP3A4
Active metabolites - DCAR, DDCAR
Half Life
Parent drug - 1-2 days
DCAR - 1-2 weeks
DDCAR - Up to 3 weeks

Elimination - Extensivly through the liver
  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart

Drug to Drug interactions of Cariprazine

CYP3A4 inducer - in combination with ketoconazole, itraconazole or even grape fruit can increase the concetration of cariprazine. Hence the strategy is to ensure low dose in combination with these drugs

CYP3A4 inhibitor ; in combination with carbamazepine, phenytoin it may reduce the concentration of serum cariprazine

The question on the page originate from the summary of the following study material:

  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo