Psychopharmacology - Antipsychotic - Cariprazine
4 important questions on Psychopharmacology - Antipsychotic - Cariprazine
Pharmacodynamic (MOA) of Cariprazine
Partial D3 Agonist - 3-10 times more affinity to D2 Agonist
Partial 5HT1A Agonist - Antidepressive and anxiolytic effect
Partial 5HT2B Antagonist - has high affinity, but yet still under study
Partial 5HT2A Antagonist - less likely to have EPS
FDA Approved indication use of Cariprazine
Bipolar Mood disorder type 1
Manic - 3-6mgdaily
Depress - 1.5mg-3mg daily
Adjunct to Major Depressive Disorder - 1.5mg to 3 mg daily
Pharmacokinetic (ADME) of Cariprazine
Active metabolites - DCAR, DDCAR
Half Life
Parent drug - 1-2 days
DCAR - 1-2 weeks
DDCAR - Up to 3 weeks
Elimination - Extensivly through the liver
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Drug to Drug interactions of Cariprazine
CYP3A4 inhibitor ; in combination with carbamazepine, phenytoin it may reduce the concentration of serum cariprazine
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