Spermatogenesis - Optimal endocrine and paracrine regulation

4 important questions on Spermatogenesis - Optimal endocrine and paracrine regulation

What is the function of testosterone and which cell produces testosterone?

  • formed by Leydig cells (LH stimulus)
    • also make oestradiol
  • gives negative feedback on hypothalamus and pituitary gland
    • High testosterone will lead to low LH levels.
    • These peaks are opposite to each other
  • stimulates function of Sertoli cells
  • stimulates spermatogenesis -> leads to divions, prevents acute degeneration and is essential for spermatid elongation
  • influences many other processes in the body

What is the reason of testosterone production?

Testosterone production is triggered by LH (pituitary gland = hypofyse) and LH release is inhibited by testosterone (indirectly). adaption is needed, so different levels of testosterone is needed to have functional sterol cells. If the testosterone levels are always high of low the sterol cells will stop reaction to testosterone. The fluctuations have a cycle of 3 hours.

What is the indirect effect of testosterone in spermatogenesis?

  • inhibits GnRH via hypothalamus (endocrine), so inhibition of FSH and LH
    • release of FSH and LH at pituitary gland is controlled by GnRH
  • production of testosterone, oestradiol, inhibin and activin by cells in testes under control of FSH and LH (paracrine)
  • release of prolactin by pituitary gland
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Which cells stimulates LH and FSH

  • LH is the leydig cell stimulation hormone
  • FSH is the steroli stimulation hormone

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