Spermatogenesis - Optimal endocrine and paracrine regulation
4 important questions on Spermatogenesis - Optimal endocrine and paracrine regulation
What is the function of testosterone and which cell produces testosterone?
- formed by Leydig cells (LH stimulus)
- also make oestradiol
- gives negative feedback on hypothalamus and pituitary gland
- High testosterone will lead to low LH levels.
- These peaks are opposite to each other
- stimulates function of Sertoli cells
- stimulates spermatogenesis -> leads to divions, prevents acute degeneration and is essential for spermatid elongation
- influences many other processes in the body
What is the reason of testosterone production?
What is the indirect effect of testosterone in spermatogenesis?
- inhibits GnRH via hypothalamus (endocrine), so inhibition of FSH and LH
- release of FSH and LH at pituitary gland is controlled by GnRH
- production of testosterone, oestradiol, inhibin and activin by cells in testes under control of FSH and LH (paracrine)
- release of prolactin by pituitary gland
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Which cells stimulates LH and FSH
- LH is the leydig cell stimulation hormone
- FSH is the steroli stimulation hormone
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