Summary: Samenvatting Trends In Stem Cell Biology
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1 Embryonic stem cells
This is a preview. There are 13 more flashcards available for chapter 1
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What are the two broad types of stem cells in mammals?
1. Embryonic stem cells (ESCs) --> which are isolated from the inner cell mass of blastocysts
2. Adult stem cells -
What are plutipotent cells (embryonic stem cells)?
Cells who are capable of differentiation into all three germlayers (ecto-, endo-, and mesoderm) -
What is multipotency in adult stem cells?
Progenitor cells (hematopoetic stem cell) -
What is oligopotency in adult stem cells?
E.g myeloid stem cell (not lymphoid lineage) -
What is unipotency in adult stem cells?
Differentiate into one cell only -
Explain the term 'waddington's landscape'
It states that the totipotent cells during development loose potency and become a single cell type. Imagine it as a totipotent ball rolling down from a hill, which is a one-way direction. -
How do you call it if you go from one mulitopotent to another mulitpotent cell?
Trans differentiation -
How do you call it if you go 'uphill' in the waddington's landscape?
Regeneration -
What are the 5 different types of pluripotent stem cells?
- Embryonic stem cells (ESCs)
- Embryonal Carcinoma cells (ECs)
- Embryonic Germ Cells (EGCs)
- Epiblast stem cells (EpiSCs; primed ES cells)
- Induced pluripotent stem cells (iPCSs)
- Embryonic stem cells (ESCs)
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What are the characteristics of pluripotency?
- They can still form every cell in an organism (ecto-, meso-, endoderm)
- self-renewal
- They can still form every cell in an organism (ecto-, meso-, endoderm)
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