Tutorial title - Intestines - Celiac disease
9 important questions on Tutorial title - Intestines - Celiac disease
What is celiac disease and what causes it?
- Genetics and environmental (gluten)
- Presence of other autoimmune diseases (Type I diabetes, autoimmune thyroid disease)
Where is the primary site affected by celiac disease?
Describe the macroscopic and microscopic morphology of celiac disease.
- Macroscopic: Edema of small intestines, inflammatory destruction.
- Microscopic: Villus atrophy (gradual blunting of villi), crypt hyperplasia.
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
What are the local clinical features of celiac disease?
- Nutritional deficiency
- Iron deficiency anemia
- Diarrhea (exudative)
- Children: failure to thrive
What are the systemic clinical features of celiac disease?
- Blister/ulcers on skin (pruritic)
- Malnutrition due to access of food and ability to utilize food
At what age do classic symptoms of celiac disease typically present?
What is the treatment approach for celiac disease?
What are the classic symptoms of celiac disease?
Classic symptoms include
- irritability
- abdominal distension
- anorexia
- diarrhea
- failure to thrive.
Explain the pathophysiology of celiac disease.
- Gliadin deamidated by tissue transglutaminase interacts with HLA-DQ2, HLA-DQ8 on APCs.
- Presented to CD4+ T cells.
- Cytokine release causing tissue damage.
- Production of AB against tissue transglutaminase, deamidated gliadin.
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding

















