Tutorial title - Hepatobiliary System - LFTs
5 important questions on Tutorial title - Hepatobiliary System - LFTs
What are the purposes of LFTs?
- Detect the presence of liver disease.
- Diagnostic evaluation (mild, moderate, severe).
- Monitor disease progression.
- Distinguish among different types of liver disorder.
How are LFTs classified under synthetic function?
- Serum proteins:
- Albumin: marker of chronicity, low serum half-life.
- Immunoglobulins: compensatory production.
- Alpha fetoprotein: screening for congenital malformation, tumor marker.
- Prothrombin time: prolonged in liver disorder, indicates liver coagulopathy.
What are the serum enzymes involved in LFTs?
- ALT, AST: indicating hepatocellular damage.
- ALP, GGT: indicating obstruction.
- Excess alcohol consumption.
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What is the detoxification function in LFTs?
- Blood ammonia: accumulates in liver & lungs.
- Hepatic encephalopathy features: cerebral edema, mutism, nervous, insomnia.
- Acute respiratory distress syndrome.
What is involved in the excretory function of LFTs?
- Serum bilirubin: conjugated, unconjugated.
- Bile: urine, bile pigments, bile salts, urobilinogen.
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