Tutorial title - Hepatobiliary System - Cholelithiasis

5 important questions on Tutorial title - Hepatobiliary System - Cholelithiasis

What are the risk factors for cholelithiasis (gallstones)?

Risk factors for cholelithiasis include:
  • Female
  • Fertile
  • Forty
  • Fat
  • Fair
  • Rapid weight loss leading to more cholesterol than bile acids.

Describe the types of stones associated with cholelithiasis.

Types of stones include:
  • Cholesterol stones: Predominant with dyslipidemia, affluent communities, and >50% crystalline cholesterol monohydrate.
  • Pigmented stones: Common in low socioeconomic groups, contain calcium salts, bilirubin, black or brown pigment.
  • Mixed stones: Combination of cholesterol, bilirubin, calcium, and phosphate.

What are the clinical features of biliary colic in gallstone disease?

Clinical features of biliary colic include:
  • RUQ pain radiating to the back
  • Pain triggered by a fatty meal
  • Associated with nausea and vomiting
  • Pain is colic in nature, occurring in a palpable or wave manner.
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What complications can arise from gallstones?

Complications from gallstones include:
  • Perforation leading to biliary peritonitis
  • Change of colic pain to constant pain
  • Absent bowel sounds
  • Multi-organ dysfunction (Chypotension)
  • CXR may show features of biliary perforation.

What factors contribute to the formation of gallstones?

Factors contributing to gallstone formation include:
  • Supersaturation of bile fluid with cholesterol
  • Decreased bile acid
  • Reduced motility
  • 80% of gallstone diseases are clinically silent
  • Stones can block ducts or cause pain.

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